Managing Miscarriage

Managing Miscarriage


Misoprostol, a synthetic prostaglandin analogue, and mifepristone, a prostaglandin and glucocorticoid receptor antagonist that primes the uterus and cervix for prostaglandin activity, can be used in the medical management of early pregnancy loss. Misoprostol alone has a high failure rate
in women with a closed cervical os, leading 15-40% of women to require a second misoprostol dose, or uterine aspiration of the gestational sac. The efficacy and safety of misoprostol and mifepristone combination therapy in early pregnancy loss remains unclear. In this randomized clinical trial of 300 women with nonviable intrauterine pregnancy, patients received pretreatment with 200 mg of mifepristone approximately 24 hours before receiving 800 mcg of misoprostol vaginally, or received misoprostol alone. Patients with a persistent gestational sac
at initial follow-up, 24 hours to 4 days after misoprostol use, could receive additional treatment. The primary outcome, treatment success, was defined as gestational sac expulsion by initial follow-up and no additional interventions within 30 days. The rate of treatment success was 83.8% among women who received mifepristone pretreatment at a median follow-up of 2 days, and 67.1% among women who received misoprostol alone at a median follow-up of 2.6 days. Thirty days after randomization, the rate
of uterine aspiration following mifepristone and misoprostol treatment was 8.8%, as compared
with 23.5% after misoprostol alone. There was no significant difference between the two treatment groups in rates of bleeding that resulted in blood transfusion. The authors conclude that mifepristone administration before misoprostol treatment resulted in a significantly higher rate of treatment success in early pregnancy loss. Full trial results at NEJM.org

6 thoughts on “Managing Miscarriage

  • I don't think the risk of prolonged endocrine disruption is worth it, for those who want more children.

  • യഥാർത്ഥ സൈറ്റോടെക് 200 എംസിജി മിസോപ്രോസ്റ്റോൾ
    dubai / uae / OMAN / BAHRAIN / KSA ൽ ലഭ്യമാണ്
    വാട്ട്‌സ്ആപ്പ് / എന്നെ വിളിക്കുക +971552363758
    yathārt'tha saiṟṟēāṭek 200 ensiji misēāprēāsṟṟēāḷ
    dubai / uae / OMAN / BAHRAIN / KSA l labhyamāṇ
    vāṭṭ‌sāpp / enne viḷikkuka +971552363758

  • Grabe talaga ang sakripisyo ko hindi madali mag paabort mabuti nalang natulongan ako miss Sam sa kanya ako nag order nang gamot maraming salamat po talaga sa inyo hindi nyo ako binigo miss kahit nasa malayo ako. Salamat po🙏

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